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"Can a test tell me if Wegovy or Zepbound will work for me?" with Dr. Andres Acosta

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September 8, 2025
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The Dr. Francavilla Show
How genetic insights are reshaping weight loss strategies—moving beyond trial-and-error toward precision-guided interventions.
Highlights:

Have you ever wondered why the same weight loss plan can work wonders for one person but barely move the needle for another?

Or why some people respond really well to medications like Wegovy, while others struggle with side effects or see little change? That's the big question behind precision obesity medicine—and today, we're diving into it with one of the leading experts in the world.

We're joined by Dr. Andres Acosta, one of the leading voices in obesity medicine and the pioneer behind the concept of obesity phenotypes. He's board-certified in internal medicine, gastroenterology, hepatology, obesity medicine, and nutrition. At the Mayo Clinic, he co-directs the Nutrition and Obesity Research Program and leads the Precision Medicine for Obesity program, where his work focuses on matching the right treatment to the right patient with fewer side effects.

His research is backed by the National Institutes of Health, with over 145 peer-reviewed papers published in top journals. His work has been featured in major outlets like The New York Times, TIME, CNN, and NPR. He's also earned "40 Under 40" recognition and co-founded Genomic Sciences—just a glimpse of his many accomplishments.

So, if you've ever felt frustrated with trial-and-error weight loss or wondered if there's a more scientific way to figure out what will actually work for you, you're going to want to hear what Dr. Acosta has to share in this episode. Keep reading—you won't want to miss this.

Read full article here.

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